Publicity about our research as well as links to things we find interesting and related to our research:
Mast cells regulate the brain-dura interface and CSF dynamics (Links to an external site)
Cerebrospinal fluid (CSF) flow is essential for brain homeostasis, and its disruption is implicated in neurodegenerative and neuroinflammatory diseases.
Meningeal lymphatics-microglia axis regulates synaptic physiology (Links to an external site)
Meningeal lymphatics serve as an outlet for cerebrospinal fluid, and their dysfunction is associated with various neurodegenerative conditions.
Endogenous self-peptides guard immune privilege of the central nervous system (Links to an external site)
Despite the presence of strategically positioned anatomical barriers designed to protect the central nervous system (CNS), it is not entirely isolated from the immune system.
Engineered T cell therapy for central nervous system injury (Links to an external site)
Using single-cell RNA sequencing, we demonstrated the clonal expansion of mouse and human spinal cord injury-associated T cells and identified that CD4+ T cell clones in mice exhibit antigen specificity towards self-peptides of myelin and neuronal proteins.
How does waste leave the brain? (Links to an external site)
Jonathan Kipnis, PhD, and fellow scientists at WashU School of Medicine have found passageways that connect the brain to vessels that carry fluid waste out of and away from the brain.
Kipnis named BJC Investigator (Links to an external site)
Leader in groundbreaking research on interaction of brain and immune system to join faculty.
The Seventh Sense (Links to an external site)
Long thought to be divorced from the brain, the immune system turns out to be intimately involved in its functioning.
Audio: A Potential ‘Missing Link’ Between the Brain and Immune System (Links to an external site)
Segment Guest: Jonathan Kipnis