(100+ publications to date)
Age-related alterations in meningeal immunity drive impaired CNS lymphatic drainage (Links to an external site)
Skull and vertebral bone marrow are myeloid cell reservoirs for the meninges and CNS parenchyma (Links to an external site)
Cugurra A, Mamuladze T, Rustenhoven J, Dykstra T, Beroshvili G, Greenberg ZJ, Baker W, Papadopoulos Z, Drieu A, Blackburn S, Kanamori M, Brioschi S, Herz J, Schuettpelz LG, Colonna M, Smirnov I, Kipnis J.
Meningeal lymphatics affect microglia responses and anti-Aβ immunotherapy (Links to an external site)
Da Mesquita S, Papadopoulos Z, Dykstra T, Brase L, Farias FG, … Benitez BA, Karch CM, Perrin RJ, Farlow M, Chhatwal JP, Holtzman DM, Cruchaga C, Harari O, Kipnis J.
Functional characterization of the dural sinuses as a neuroimmune interface (Links to an external site)
Rustenhoven J, Drieu A, Mamuladze T, de Lima KA, Dykstra T, Wall M, Papadopoulos Z, Kanamori M, Salvador AF, Baker W, Lemieux M, Da Mesquita S, Cugurra A, Fitzpatrick J, Sviben S, Kossina R, Bayguinov P, Townsend RR, Zhang Q, Erdmann-Gilmore P, Smirnov I, Lopes MB, Herz J, Kipnis J.
Meningeal γδ T cells regulate anxiety-like behavior via IL-17a signaling in neurons (Links to an external site)
Alves de Lima K, Rustenhoven J, Da Mesquita S, Wall M, Salvador AF, Smirnov I, Martelossi Cebinelli G, Mamuladze T, Baker W, Papadopoulos Z, Lopes MB, Cao WS, Xie XS, Herz J, Kipnis J.
CNS lymphatic drainage and neuroinflammation are regulated by meningeal lymphatic vasculature (Links to an external site)
Louveau A, Herz J, Alme MN, Salvador AF, Dong MQ, Viar KE, Herod SG, Knopp J, Setliff JC, Lupi AL, Da Mesquita S, Frost EL, Gaultier A, Harris TH, Cao R, Hu S, Lukens JR, Smirnov I, Overall CC, Oliver G, Kipnis J.
Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease (Links to an external site)
Da Mesquita S, Louveau A, Vaccari A, Smirnov I, Cornelison RC, Kingsmore KM, Contarino C, Onengut-Gumuscu S, Farber E, Raper D, Viar KE, Powell RD, Baker W, Dabhi N, Bai R, Cao R, Hu S, Rich SS, Munson JM, Lopes MB, Overall CC, Acton ST, Kipnis J.
Unexpected role of interferon-γ in regulating neuronal connectivity and social behaviour (Links to an external site)
Filiano AJ, Xu Y, Tustison NJ, Marsh RL, Baker W, Smirnov I, Overall CC, Gadani SP, Turner SD, Weng Z, Peerzade SN, Chen H, Lee KS, Scott MM, Beenhakker MP, Litvak V, Kipnis J.
Structural and functional features of central nervous system lymphatics (Links to an external site)
Louveau A, Smirnov I, Keyes TJ, Eccles JD, Rouhani SJ, Peske JD, Derecki NC, Castle D, Mandell JW, Lee KS, Harris TH, Kipnis J.
Methyl-CpG Binding Protein 2 Regulates Microglia and Macrophage Gene Expression in Response to Inflammatory Stimuli (Links to an external site)
Cronk JC, Derecki NC, Ji E, Xu Y, LampanoA, Smirnov I, Baker W, Norris GT, Coddington N, Wolf Y, Klibanov AL, HarrisTH, Jung S, Litvak V, and Kipnis J.
The glia-derived alarmin IL-33 orchestrates the post CNS injury immune response and promotes recovery (Links to an external site)
Gadani SP, Walsh JT, Smirnov I, Zheng J and Kipnis J.